Selective Inhibition of the Tumor Marker AKR1B10 by Antiinflammatory N-Phenylanthranilic Acids and Glycyrrhetic Acid
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چکیده
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Selective Inhibition by Clofibric Acid
shown to actively utilize branched chaini amino acids and to produce alanine. The coniversioni of [1-"C]leucine to 14CO2 or to the [1-14C]keto-acid of leucine (a-keto-isocaproate) was linear for at least 2 h of incubation; the production of "CO2 from [1-'4C]leucine was saturable with a Km = 6.3 mM and a maximiium oxidation rate (Vmax) = 31 nmiol/mg protein per 120 min. Clofibric acid selectivel...
متن کاملTumor-selective inhibition of the incorporation of 3H-labeled amino acids into protein by cyanate.
Sodium cyanate at a dose level of 125 or 250 mg/kg i.p. caused an inhibition of incorporation of 3H-labeled amino acids into cytoplasmic and nuclear proteins of the rapidly growing hepatoma 7777 and the slowly growing hepatoma 9618A. There was no inhibitory effect on 3H-labeled amino acid incorporation into protein in the livers of rats bearing these tumors. Studies on the effects of sodium cya...
متن کاملStructural basis for the high all-trans-retinaldehyde reductase activity of the tumor marker AKR1B10.
AKR1B10 is a human aldo-keto reductase (AKR) found to be elevated in several cancer types and in precancerous lesions. In vitro, AKR1B10 exhibits a much higher retinaldehyde reductase activity than any other human AKR, including AKR1B1 (aldose reductase). We here demonstrate that AKR1B10 also acts as a retinaldehyde reductase in vivo. This activity may be relevant in controlling the first step ...
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چکیده ندارد.
15 صفحه اولSelective Inhibition by Sorbylhydroxamic Acid of Deoxyribonucleic Acid Synthesis in Ehrlich Ascites Tumor Cells1
Sorbylhydroxamic acid (SOHA) inhibited the incorporation in vitro of thymidine into deoxyribonucleic acid in Ehrlich ascites tumor cells, with no appreciable effect on the incorporation of uridine into ribonucleic acid or of L-leucine into protein. Hexanoylhydroxamic acid, devoid of the conjugated double-bond system, had no such activity. The concentration of SOHA conferring 50% inhibition of D...
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ژورنال
عنوان ژورنال: Biological and Pharmaceutical Bulletin
سال: 2010
ISSN: 0918-6158,1347-5215
DOI: 10.1248/bpb.33.886